Tumor necrosis factor-α induces apoptosis in rat brown adipocytes
نویسندگان
چکیده
منابع مشابه
p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes.
Tumor necrosis factor-alpha (TNFalpha) induces apoptosis and cell growth inhibition in primary rat fetal brown adipocytes. Here, we examine the role played by some members of the mitogen-activated protein kinase (MAPK) superfamily. TNFalpha activates extracellular regulated kinase-1/2 (ERK1/2) and p38MAPK. Inhibition of p38MAPK by either SB203580 or SB202190 highly reduces apoptosis induced by ...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 1997
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400292